Transport properties of aqueous solutions of the oncologic drug 5-fluorouracil: A fundamental complement to therapeutics

Cancer pharmacology is often markedly toxic and must be precisely dosed in order to reach the therapeutic bioavailability under strict control. Transport properties are important tools process of interpretation fine-tuning pharmaceutical applications, notably for drugs that have a long record use met their limits bioavailability. 5–Fluorouracil (5-FU) one most used antineoplastic agents since its discovery 1957. In this paper, binary mutual diffusion coefficients 5-fluorouracil, obtained from Taylor dispersion method setup reported aqueous solutions up 75 mmol.kg?1. These data were complemented by viscosity measurements. The overall information allows compute descriptive parameters further on basis well-established models.